Immune-Regulatory Mechanisms in Systemic Autoimmune and Rheumatic Diseases
نویسندگان
چکیده
منابع مشابه
Immune-Regulatory Mechanisms in Systemic Autoimmune and Rheumatic Diseases
Autoimmune diseases encompass a wide range of organ-specific and systemic disorders with a complex etiology. An intricate interplay of genetic, environmental, as well as immunological factors leads to the development of these debilitating diseases. In the absence of infections, regulatory processes inhibit immune responses towards antigen. Moreover , the immune system has multiple levels of neg...
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Systemic autoimmune and rheumatic diseases (SAIRDs) are thought to develop due to the failure of autoimmune regulation and tolerance. Current therapies, such as biologics, have improved the clinical results of SAIRDs; however, they are not curative treatments. Recently, new discoveries have been made in immune tolerance and inflammation, such as tolerogenic dendritic cells, regulatory T and B c...
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Autoimmune diseases (AIDs) have been associated with accelerated atherosclerosis (AT) leading to increased cardio- and cerebrovascular disease risk. Traditional risk factors, as well as systemic inflammation mediators, including cytokines, chemokines, proteases, autoantibodies, adhesion receptors, and others, have been implicated in the development of these vascular pathologies. Yet, the charac...
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The aim of this study was to determine whether inflammation is related to cancer development, and whether the incidence of cancer is increased and occurs in a site-specific manner in patients with systemic autoimmune rheumatic diseases (SARDs).This study included a nationwide dynamic cohort of patients with various newly diagnosed SARDs from 1997 to 2010 with follow-up until 2012.This study inc...
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1 Center for Autoimmune Diseases Research (CREA), Universidad del Rosario, Carrera 24 No. 63C-69, 111221 Bogota, Colombia 2 ZabludowitczCenter forAutoimmuneDiseases, ShebaMedical Center, Tel-Hashomer, Sackler Faculty ofMedicine, Tel AvivUniversity, 52621 Tel-Hashomer, Israel 3 Department of Rheumatology and Clinical Immunology, Charité Universitätsmedizin Charitéplatz 1, 10117 Berlin, Germany 4...
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ژورنال
عنوان ژورنال: Clinical and Developmental Immunology
سال: 2012
ISSN: 1740-2522,1740-2530
DOI: 10.1155/2012/957151